Targeting Sonic Hedgehog Signaling by Compounds and …

Targeting Sonic Hedgehog Signaling by Compounds and …

In this review, we summarize investigations of the compounds cyclopamine, curcumin, epigallocatechin-3-gallate, genistein, resveratrol, zerumbone, norcantharidin, and arsenic trioxide, with a focus on Shh signaling blockade. Given that Shh …. The major extract zerumbone has been shown to increase apoptosis and inhibit cancer cell invasion and has demonstrated antitumor effects against leukemia and breast, lung, liver, and pancreatic cancers [46–49]. Hosoya et …

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