STAT inhibitors for cancer therapy – Journal of Hematology …

STAT inhibitors for cancer therapy – Journal of Hematology …

Activity of STAT3 was also inhibited in breast, prostate and cervical cancer cell lines. Study of binding mechanism revealed that cryptotanshinone directly interact with SH2 domain of STAT3 to … Curcumin (diferuloylmethane; IC50 20 μM in PC-3 prostate cancer cell lines), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways. Promising effects of this compound are seen in many conditions including cardiovascular …

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