Novel STAT3 Phosphorylation Inhibitors Exhibit Potent …

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent …

… is thus an attractive therapeutic approach for these cancers. We have recently developed novel small-molecule STAT3 inhibitors, known as FLLL31 and FLLL32, which are derived from curcumin (the primary bioactive compound of turmeric). … Our findings highlight the potential of these new compounds and their efficacy in targeting pancreatic and breast cancers that exhibit constitutive STAT3 signaling. Cancer Res; 70(6); 2445–54. Keywords. Pancreatic cancer …

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