Curcumin and AD. 1. SIRT1 and Resveratrol and Alzheimer's Disease. I have discussed the SIRT1 gene and protein in numerous contexts in this blog. In the blog entry SIRT1, mTOR, NF-kappaB and resveratrol I mentioned links between SIRT1 activation, mTOR …. While I have not independently verified the statements and citations therein, the October 2, 2007 item Turmeric and Alzheimer 's disease by Jacob Schor, ND appears to me to be particularly informative.